The key-muscle concept: a long-term low-dose injection strategy for botulinum toxin A treatment in cerebral palsy.

Abstract

Botulinum toxin (BoNT) is a well established treatment in cerebral palsy. A uniform dose strategy is, however, missing. We reviewed 35 children with spastic cerebral palsy treated with BoNT according to a newly-developed Key-Muscle concept. All patients received at least 4 BoNT treatments. Systemic side effects or secondary non-response were not observed. After a mean follow-up of 303 months, none of these patients needed bone surgery whereas 6 underwent soft tissue procedures. The Key-Muscle concept is a safe and effective treatment in spastic cerebral palsy. It respects the need for long-term therapy during motor development. Contractures and lever arm disease can be avoided.

• Authors: Richard Placzek, Khaled Hamed Salem, Ludwig A Meiss, Dagmar Siebold, Wolf Drescher
• Journal: Acta orthopaedica Belgica (Acta Orthop Belg) Vol. 78 Issue 1 Pg. 111-6 (Feb 2012) ISSN: 0001-6462 [Print] Belgium
• PMID: 22523937 (Publication Type: Journal Article)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A
• abobotulinumtoxinA

Topics

• Botulinum Toxins, Type A (administration & dosage)
• Cerebral Palsy (drug therapy)
• Child
• Child, Preschool
• Female
• Humans
• Injections, Intramuscular (methods)
• Male
• Neuromuscular Agents (administration & dosage)
• Retrospective Studies