Abstract | BACKGROUND: METHODS AND FINDINGS: To determine if Tregs contribute to this protection, we performed immunologic and Treg depletion in vitro studies using PBMC acquired from children with and without S. haematobium infection followed longitudinally for the acquisition of malaria. Levels of Tregs were lower in children with dual infections compared to children with malaria alone (0.49 versus 1.37%, respectively, P = 0.004) but were similar months later, during a period with negligible malaria transmission. The increased levels of Tregs in SN subjects were associated with suppressed serum Th1 cytokine levels, as well as elevated parasitemia compared to co-infected counterparts. CONCLUSIONS: These results suggest that lower levels of Tregs in helminth-infected children correlate with altered circulating cytokine and parasitologic results which may play a partial role in mediating protection against falciparum malaria.
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Authors | Kirsten E Lyke, Abdoulaye Dabo, Charles Arama, Modibo Daou, Issa Diarra, Amy Wang, Christopher V Plowe, Ogobara K Doumbo, Marcelo B Sztein |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 2
Pg. e31647
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22348117
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Blood Cells
(immunology)
- Cells, Cultured
- Child
- Child, Preschool
- Coinfection
(immunology)
- Cytokines
(blood)
- Humans
- Longitudinal Studies
- Malaria, Falciparum
(immunology)
- Parasitemia
- Plasmodium falciparum
(immunology)
- Schistosoma haematobium
(immunology)
- Schistosomiasis haematobia
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
- Th1 Cells
(immunology)
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