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Fig latex (Ficus carica L. cultivar Dottato) in combination with UV irradiation decreases the viability of A375 melanoma cells in vitro.

Abstract
Melanoma and nonmelanoma skin cancers are among the most prevalent cancers in the human population. In the present work latex of Ficus carica cultivar Dottato from Italy collected from fruits and leaves was examined to assess its free radical-scavenging activity with 1,1-diphenyl-2 picrylhydrazyl (DPPH) and its phototoxicity on A375 human melanoma cells. The latex obtained from the fruits of Ficus carica cv. Dottato showed the best antiradical activity with an IC50 value of 0.05 mg/ml while the latex obtained from the leaves showed the best antiproliferative activity with an IC50 value of 1.5 μg/ml on the human tumor cell line A375 (melanoma) after irradiation at a specific UVA dose (1.08 J/cm2). Control experiments with UVA light or drugs alone were carried out without significant cytotoxic effects. Polyphenolic content of the samples was also evaluated. This is the first study comparing F. carica latex of leaves and fruits. Plant derived natural products have long been and will continue to be an important source for anticancer drug development.
AuthorsGiulio Menichini, Carmine Alfano, Eugenio Provenzano, Mariangela Marrelli, Giancarlo A Statti, Francesco Somma, Francesco Menichini, Filomena Conforti
JournalAnti-cancer agents in medicinal chemistry (Anticancer Agents Med Chem) Vol. 12 Issue 8 Pg. 959-65 (Oct 01 2012) ISSN: 1875-5992 [Electronic] Netherlands
PMID22339064 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Biological Products
  • Latex
  • Plant Extracts
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Biological Products (chemistry, isolation & purification, pharmacology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects)
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Ficus (chemistry)
  • Fruit (chemistry)
  • Humans
  • Latex (chemistry, isolation & purification, pharmacology)
  • Melanoma (drug therapy, pathology)
  • Plant Extracts (chemistry)
  • Plant Leaves (chemistry)
  • Structure-Activity Relationship
  • Ultraviolet Rays

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