Abstract | OBJECTIVE: To study clinicopathological features, diagnosis, differential diagnosis of oral Langerhans cell histiocytosis (LCH), retrospective clinicopathologic study was carried on and a variety of immune phenotype were detected. METHODS: The clinicopathological features of 29 cases of oral LCH were analyzed. The immunohistochemical staining of S-100 protein, CD1a, CD83 and Ki-67 were used in above cases by immunohistochemical streptavidin- biotin peroxidase (SP) and Elivison two-step method. Statistical analysis was adopted for the results. RESULTS: Of the 29 cases of LCH, the expression of S-100 protein and CD1a were positive in 24 cases and negative in 5 cases, so 5 cases were excluded from the diagnosis of LCH. Among 24 cases of LCH, 15 patients were male and 9 were female. The median age was 7.50 years. 14 lesions were in the mandible, 5 were in the maxilla and 5 involved the mandible and maxilla. 9 cases were in stage I, 13 in stage II and 2 in stage III, according to Bartnick classification. Immunohistochemistry showed all 24 cases staining for S-100 protein and CD1a were positive. Comparing with maxillofacial lesions involved soft tissue, Ki-67 positive rate was lower and CD83 positive rate was higher in maxillofacial single bone lesion. CONCLUSION: The immunohistochemical staining of S-100 protein and CD1a are important for the diagnosis of LCH. Maxillofacial bone single LCH might have lower proliferative activity and a higher state of maturity. Maxillofacial LCH involved soft tissue might have a higher proliferative activity and a lower state of maturity.
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Authors | Ye Zhao, Yage Zheng, Lihui Zhang, Tian Yao, Lanyan Wu |
Journal | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
(Hua Xi Kou Qiang Yi Xue Za Zhi)
Vol. 29
Issue 6
Pg. 604-9
(Dec 2011)
ISSN: 1000-1182 [Print] China |
PMID | 22332572
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD1
- CD1a antigen
- S100 Proteins
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Topics |
- Antigens, CD1
- Diagnosis, Differential
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Male
- Mandible
- Maxilla
- Retrospective Studies
- S100 Proteins
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