Expression of protein kinase C isoforms in cancerous breast tissue and adjacent normal breast tissue.

Abstract

The role of protein kinase C (PKC) in the carcinogenesis of human breast tissue has been studied at the molecular level for more than two decades. In this study, we employed Western blotting to determine the presence of PKC isoforms in cancerous and normal breast tissues. The results indicate significant expression of a conventional PKC (PKCα) and two atypical PKCs (PKC ζ and λ/ι) in both breast tumors and adjacent normal breast tissue. For the α,ζ and λ/ι isoforms, the expression of individual isoforms was higher in the breast tumors than in the adjacent normal breast tissue. Although the correlation coefficient was low, significant linear correlation was found among the activities of the isoforms. The data suggest a potential new direction in cancer chemotherapy, namely the blockage of the signal transduction pathway of specific PKC isoforms.

• Authors: Yueh-Min Lin, Cheng-Chuan Su, Wei-Wen Su, Jin-Ming Hwang, Hsi-Hsien Hsu, Chang-Hai Tsai, Yen-Chu Wang, Fuu-Jen Tsai, Chih-Yang Huang, Jer-Yuh Liu, Li-Mien Chen
• Journal: The Chinese journal of physiology (Chin J Physiol) Vol. 55 Issue 1 Pg. 55-61 (Feb 29 2012) ISSN: 0304-4920 [Print] India
• PMID: 22242955 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoenzymes
• Protein Kinase C

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (enzymology)
• Carcinoma, Ductal, Breast (enzymology)
• Female
• Humans
• Isoenzymes (metabolism)
• Middle Aged
• Protein Kinase C (metabolism)
• Young Adult