Abstract | BACKGROUND: OBJECTIVE: The aim of this study is to examine the expression profile of cathepsin K in both the tumour cells and the peritumoural stromal cells of BCC in comparison with its expression in normal skin. METHODS: RESULTS: In normal skin, cathepsin K expression was observed in the stratum corneum, mature sebaceous cells and outer root sheath of the hair follicles. Cathepsin K was expressed in the tumour cells of all BCC cases, in which 90% showed diffuse expression (>51% of tumour cells), as well as in the peritumoural stromal cells in all BCC cases. Focal cathepsin K expression was observed in the tumour cells of Bowen's disease (2/10 cases), but not in any of actinic keratosis (0/10 cases). CONCLUSION:
Cathepsin K expression may contribute to tumour invasion and peculiar histopathological features, such as fibromucinous stroma around the tumour nests by mediating extracellular matrix degradation in BCC.
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Authors | M Ishida, F Kojima, H Okabe |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 27
Issue 1
Pg. e128-30
(Jan 2013)
ISSN: 1468-3083 [Electronic] England |
PMID | 22220587
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. |
Chemical References |
- Biomarkers, Tumor
- Cathepsin K
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Biopsy, Needle
- Bowen's Disease
(enzymology, pathology, surgery)
- Carcinoma, Basal Cell
(enzymology, pathology, surgery)
- Case-Control Studies
- Cathepsin K
(metabolism)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Keratosis, Actinic
(enzymology, pathology, surgery)
- Male
- Middle Aged
- Neoplasm Invasiveness
(pathology)
- Prognosis
- Reference Values
- Risk Assessment
- Skin Neoplasms
(enzymology, pathology, surgery)
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