Abstract | BACKGROUND: MATERIALS AND METHODS: Human gastric cancer MKN45 cells were injected into the peritoneal cavity of immune-deficient NOD-SCID mice. After induction of PC, the animals were randomized into five groups: HIPEC with mitomycin and cisplatin; normothermic intraperitoneal chemotherapy (NIPEC); normothermic intraperitoneal saline; hyperthermic intraperitoneal saline alone; no treatment. After 10 days of treatment, the mice were sacrificed and the extent of PC was assessed. RESULTS: CONCLUSION: In the present study we have provided evidence that HIPEC protects against peritoneal dissemination in a mouse model of peritoneal gastric carcinogenesis and brings about specific changes in gene expression wich may be related to this protection.
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Authors | Luigina Graziosi, Andrea Mencarelli, Barbara Renga, Chiara Santorelli, Francesco Cantarella, Walter Bugiantella, Emanuel Cavazzoni, Annibale Donini, Stefano Fiorucci |
Journal | In vivo (Athens, Greece)
(In Vivo)
2012 Jan-Feb
Vol. 26
Issue 1
Pg. 39-45
ISSN: 1791-7549 [Electronic] Greece |
PMID | 22210714
(Publication Type: Journal Article)
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Chemical References |
- Adenomatous Polyposis Coli Protein
- Integrin beta3
- Receptors, CXCR4
- Mitomycin
- Cisplatin
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Topics |
- Adenomatous Polyposis Coli Protein
(genetics)
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Cell Line, Tumor
- Chemotherapy, Cancer, Regional Perfusion
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Hyperthermia, Induced
(methods)
- Injections, Intraperitoneal
- Integrin beta3
(genetics)
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Mitomycin
(administration & dosage)
- Oligonucleotide Array Sequence Analysis
- Peritoneal Neoplasms
(genetics, secondary, therapy)
- Random Allocation
- Receptors, CXCR4
(genetics)
- Stomach Neoplasms
(genetics, pathology, therapy)
- Survival Analysis
- Xenograft Model Antitumor Assays
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