Abstract | BACKGROUND: METHODS: To better understand the pathogenesis and natural history of indium lung disease, a detailed, systematic, multidisciplinary analysis of clinical, histopathologic, radiologic, and epidemiologic data for all reported cases and workplaces was undertaken. RESULTS: Ten men (median age, 35 years) who produced, used, or reclaimed indium compounds were diagnosed with interstitial lung disease 4-13 years after first exposure (n = 7) or PAP 1-2 years after first exposure (n = 3). Common pulmonary histopathologic features in these patients included intraalveolar exudate typical of alveolar proteinosis (n = 9), cholesterol clefts and granulomas (n = 10), and fibrosis (n = 9). Two patients with interstitial lung disease had pneumothoraces. Lung disease progressed following cessation of exposure in most patients and was fatal in two. Radiographic data revealed that two patients with PAP subsequently developed fibrosis and one also developed emphysematous changes. Epidemiologic investigations demonstrated the potential for exposure to respirable particles and an excess of lung abnormalities among coworkers. CONCLUSIONS:
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Authors | Kristin J Cummings, Makiko Nakano, Kazuyuki Omae, Koichiro Takeuchi, Tatsuya Chonan, Yong-Long Xiao, Russell A Harley, Victor L Roggli, Akira Hebisawa, Robert J Tallaksen, Bruce C Trapnell, Gregory A Day, Rena Saito, Marcia L Stanton, Eva Suarthana, Kathleen Kreiss |
Journal | Chest
(Chest)
Vol. 141
Issue 6
Pg. 1512-1521
(Jun 2012)
ISSN: 1931-3543 [Electronic] United States |
PMID | 22207675
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
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Chemical References |
- Biomarkers
- Pancreatitis-Associated Proteins
- REG3A protein, human
- Indium
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Topics |
- Adult
- Biomarkers
(analysis)
- Bronchoscopy
- Diagnosis, Differential
- Disease Progression
- Humans
- Indium
(toxicity)
- Lung Diseases
(chemically induced, diagnosis)
- Male
- Occupational Diseases
(chemically induced, diagnosis)
- Occupational Exposure
(adverse effects)
- Pancreatitis-Associated Proteins
- Respiratory Function Tests
- Risk Factors
- Tomography, X-Ray Computed
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