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Pulmonary Alveolar Proteinosis

A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
Also Known As:
Alveolar Proteinoses, Pulmonary; Alveolar Proteinosis, Pulmonary; Proteinoses, Pulmonary Alveolar; Proteinosis, Pulmonary Alveolar; Pulmonary Alveolar Proteinoses
Networked: 789 relevant articles (55 outcomes, 31 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lung Diseases (Lung Disease)
2. Respiratory Insufficiency (Respiratory Failure)
3. Hypoxia (Hypoxemia)
4. Interstitial Lung Diseases (Interstitial Lung Disease)
5. Neoplasms (Cancer)

Experts

1. Nakata, Koh: 44 articles (01/2021 - 02/2004)
2. Trapnell, Bruce C: 34 articles (01/2022 - 01/2002)
3. Inoue, Yoshikazu: 27 articles (11/2021 - 12/2004)
4. Tazawa, Ryushi: 24 articles (01/2021 - 05/2005)
5. Suzuki, Takuji: 22 articles (01/2022 - 04/2008)
6. Griese, Matthias: 20 articles (01/2022 - 04/2004)
7. Arai, Toru: 20 articles (11/2021 - 12/2004)
8. Thomassen, Mary Jane: 20 articles (01/2020 - 10/2002)
9. Kavuru, Mani S: 18 articles (09/2013 - 04/2002)
10. Bonella, Francesco: 14 articles (01/2022 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pulmonary Alveolar Proteinosis:
1. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
2. Surface-Active Agents (Surfactants)IBA
3. Acetaminophen (Paracetamol)FDA LinkGeneric
4. AutoantibodiesIBA
5. Proteins (Proteins, Gene)FDA Link
6. Rituximab (Mabthera)FDA Link
7. sargramostim (Leukine)FDA Link
8. Oxygen (Dioxygen)IBA
9. lipoarabinomannan (LAM)IBA
10. NF-kappa B (NF-kB)IBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Respiratory Therapy (Therapy, Respiratory)
4. General Anesthesia
5. Plasmapheresis