The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children.

Abstract	The association between inosine triphosphate pyrophosphatase (ITPA) activity and toxicity of 6-mercaptopurine (6-MP) was retrospectively evaluated in 65 Japanese children with acute lymphoblastic leukemia (ALL). Patients with an ITPA activity of less than 126 μmol/h/gHb presented with hepatotoxicity more frequently than those with higher ITPA activity (p<0.01). The average 6-MP dose during maintenance therapy administered to two patients with the ITPA deficiency was lower than that given to the other patients. Measuring ITPA activity is important for ensuring the safety of maintenance therapy for Asians with ALL because thiopurine S-methyl transferase mutations are rare in the Asian population.
Authors	Yoichi Tanaka, Atsushi Manabe, Hisaya Nakadate, Kensuke Kondoh, Kozue Nakamura, Katsuyoshi Koh, Tomoyuki Utano, Akira Kikuchi, Takako Komiyama
Journal	Leukemia research (Leuk Res) Vol. 36 Issue 5 Pg. 560-4 (May 2012) ISSN: 1873-5835 [Electronic] England
PMID	22200619 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright Â© 2011 Elsevier Ltd. All rights reserved.
Chemical References	Antimetabolites, Antineoplastic Mercaptopurine Pyrophosphatases ITPA protein, human
Topics	Adolescent Antimetabolites, Antineoplastic (adverse effects) Child Child, Preschool Female Humans Infant Male Mercaptopurine (adverse effects) Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy) Pyrophosphatases (metabolism) Retrospective Studies

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