Optic neuritis after infliximab therapy.

Abstract

Demyelinating diseases were described in patients receiving anti-TNF agents. Optic neuritis (ON) induced by TNF blockers was already described in 22 cases in the literature. In this article, the authors report a 53-year-old woman with refractory rheumatoid arthritis that developed neuritis optica after the fourth dose of infliximab and had a good outcome after anti-TNF withdrawal, associated with glucocorticoid treatment. In addition, the previous cases of ON induced by anti-TNF agents were reviewed.

• Authors: César Faillace, João Ricardo Maltez de Almeida, Jozélio Freire de Carvalho
• Journal: Rheumatology international (Rheumatol Int) Vol. 33 Issue 4 Pg. 1101-3 (Apr 2013) ISSN: 1437-160X [Electronic] Germany
• PMID: 22198693 (Publication Type: Case Reports, Letter)

Chemical References

• Antibodies, Monoclonal
• Antirheumatic Agents
• Immunologic Factors
• Tumor Necrosis Factor-alpha
• Infliximab

Topics

• Antibodies, Monoclonal (adverse effects, therapeutic use)
• Antirheumatic Agents (adverse effects, therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Female
• Humans
• Immunologic Factors (adverse effects, therapeutic use)
• Infliximab
• Middle Aged
• Optic Neuritis (chemically induced)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)