Abstract | OBJECTIVE: SUBJECTS AND METHODS: • Epidemiological survey of urological symptoms among men and women aged 30-79 years. A multi-stage stratified cluster design was used to randomly sample 5503 adults from the city of Boston. Analyses were conducted on 1898 men and 1854 women with available CRP levels. • The International Continence Society defines OAB as 'Urgency with or without urge incontinence, usually with frequency and nocturia.' OAB was defined as: (1) urgency, (2) urgency with frequency, and (3) urgency with frequency and nocturia. • Odds ratios (OR) and 95% confidence intervals (95% CI) of the CRP and OAB association were estimated using logistic regression. RESULTS: • Prevalence of OAB increased with CRP levels in both men and women. • In men, adjusted ORs (95% CI) per log(10) (CRP) levels were 1.90 (1.26-2.86) with OAB defined as urgency, 1.65 (1.06-2.58) with OAB defined as urgency and frequency, and 1.92 (1.13-3.28) with OAB defined as urgency, frequency and nocturia. • The association was more modest in women with ORs (95% CI) of 1.53 (1.07-2.18) for OAB as defined urgency, 1.51 (1.02-2.23) for OAB defined as urgency and frequency, and 1.34 (0.85-2.12) for OAB defined as urgency, frequency and nocturia. CONCLUSIONS: • Results show a consistent association of increasing CRP levels and OAB among both men and women. • These results support our hypothesis for the role of inflammation in the development of OAB and a possible role for anti-inflammatory agents in its treatment.
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Authors | Varant Kupelian, Raymond C Rosen, Claus G Roehrborn, Pradeep Tyagi, Michael B Chancellor, John B McKinlay |
Journal | BJU international
(BJU Int)
Vol. 110
Issue 3
Pg. 401-7
(Aug 2012)
ISSN: 1464-410X [Electronic] England |
PMID | 22176817
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2011 BJU INTERNATIONAL. |
Chemical References |
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Topics |
- Adult
- Aged
- Boston
(epidemiology)
- C-Reactive Protein
(metabolism)
- Cohort Studies
- Cystitis
(blood, complications, epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Prevalence
- Risk Factors
- Urinary Bladder, Overactive
(blood, epidemiology, etiology)
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