Abstract | PURPOSE: METHODS: Skin AF was measured using AGE Reader in 310 patients: 157 haemodialysis patients (HD) (mean age 60 years, dialysis vintage 29 months, 19.1% diabetic), 102 peritoneal dialysis patients (PD) (mean age 56.3 years, dialysis vintage 16 months, 17.6% diabetic), 32 CKD patients (mean age 68 years, CKD duration 30 months, 34.4% diabetic) and 19 type 2 diabetic patients, without renal failure (mean age 59 years and median duration of diabetes 36 months). RESULTS: HD patients have higher AGE levels compared to PD ones. Dialysis patients have the highest skin AF values compared to CKD patients (P < 0.05) and diabetic, without renal impairment, patients (P < 0.01). Skin AF levels in patients using ARBs and statins are comparable to those without treatment in dialysis group (HD + PD) but significantly different in PD sub-group and CKD patients. In dialysis patients, diabetes explains 17% of AGE values variance. In PD skin, AF correlates with CKD duration (P < 0.01) and dialysis vintage (P < 0.05). Skin AF values were significantly higher in anuric PD patients (P < 0.05). In our CKD group, we found no significant association with diabetes or GFR. CONCLUSIONS: CKD patients have higher AGE values depending on duration (disease, RRT) and GFR (dialysis adequacy and RRF). Other important determinants were diabetes and age.
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Authors | Mihaela Oleniuc, Adalbert Schiller, Irina Secara, Mihai Onofriescu, Simona Hogas, Mugurel Apetrii, Dimitrie Siriopol, Adrian Covic |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 44
Issue 5
Pg. 1441-9
(Oct 2012)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 22160646
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin Receptor Antagonists
- Anticholesteremic Agents
- Antihypertensive Agents
- Biomarkers
- Blood Glucose
- Glycation End Products, Advanced
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Adult
- Age Factors
- Aged
- Angiotensin Receptor Antagonists
(pharmacology)
- Anticholesteremic Agents
(pharmacology)
- Antihypertensive Agents
(pharmacology)
- Biomarkers
(metabolism)
- Blood Glucose
- Cardiovascular Diseases
(complications, metabolism)
- Diabetes Mellitus, Type 2
(complications, metabolism)
- Female
- Glomerular Filtration Rate
- Glycation End Products, Advanced
(drug effects, metabolism)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacokinetics)
- Male
- Middle Aged
- Multivariate Analysis
- Optical Imaging
- Peritoneal Dialysis
- Renal Dialysis
- Renal Insufficiency, Chronic
(complications, metabolism, therapy)
- Skin
(metabolism)
- Statistics, Nonparametric
- Time Factors
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