Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer.

Abstract

We elucidated the relationship between prognosis of non-small-cell lung cancer (NSCLC) and Wilms' tumor gene (WT1) mRNA expression in tumor tissue. The WT1 mRNA expression levels of the fatal cases were lower as compared with those of the survival cases. Overall survival (OS) and disease-free survival (DFS) of the high WT1 expression group were longer than of the low expression group. As for squamous cell lung cancer (SQLC), low WT1 expression was significantly associated with lymph node metastasis. Cox analysis revealed that the gene level was a significant prognostic factor in OS and DFS. Low WT1 expression predicted poor prognosis in patients with NSCLC.

• Authors: Seiji Hayashi, Yusuke Oji, Yuko Kanai, Tomoaki Teramoto, Masanori Kitaichi, Tomoya Kawaguchi, Masaji Okada, Haruo Sugiyama, Akihide Matsumura
• Journal: Cancer investigation (Cancer Invest) Vol. 30 Issue 2 Pg. 165-71 (Feb 2012) ISSN: 1532-4192 [Electronic] England
• PMID: 22148937 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• WT1 Proteins

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (genetics, metabolism)
• Disease-Free Survival
• Female
• Gene Expression
• Genes, Wilms Tumor
• Humans
• Lung Neoplasms (genetics, metabolism)
• Male
• Middle Aged
• Prognosis
• RNA, Messenger (biosynthesis, genetics)
• WT1 Proteins (biosynthesis, genetics)