Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.

Abstract

RNA binding protein acheron has proved to be either the mediator of integrin-extracellular matrix interactions or the regulatory factor that participates in vertebrate development, cell differentiation and cell death. We report the role of acheron in vascular endothelial proliferation, angiogenesis and wound healing post-trauma. Co-immunoprecipitation showed that Acheron forms a ternary complex with β1 integrin and Id1 in human umbilical vein endothelial cells following stimulation with serious trauma serum. Acheron, vascular endothelial growth factor (VEGF), and β1 integrin mRNA expression was apparently inhibited, and capillary density and wound healing rate also were reduced in Id1-deficient mice trauma model. Acheron together with Id1 significantly induces VEGF, not CD105 level inhibition by serious trauma serum for 24 h. In conclusion, we have demonstrated that acheron may be an effective mediator of promoting endothelial proliferation, angiogenesis and wound healing probably by regulating VEGF together with Id1.

• Authors: Rongju Sun, Wei Chen, Xiaodong Zhao, Tanshi Li, Qing Song
• Journal: Cell biochemistry and function (Cell Biochem Funct) Vol. 29 Issue 8 Pg. 636-40 (Dec 2011) ISSN: 1099-0844 [Electronic] England
• PMID: 22139627 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 John Wiley & Sons, Ltd.

Chemical References

• Autoantigens
• Inhibitor of Differentiation Protein 1
• Ribonucleoproteins
• Vascular Endothelial Growth Factor A

Topics

• Animals
• Autoantigens (genetics, metabolism)
• Cell Proliferation
• Cells, Cultured
• Endothelial Cells (cytology, metabolism)
• Female
• Humans
• Inhibitor of Differentiation Protein 1 (genetics, metabolism)
• Male
• Mice
• Mice, Knockout
• Neovascularization, Physiologic
• Protein Binding
• Ribonucleoproteins (genetics, metabolism)
• Vascular Endothelial Growth Factor A (genetics, metabolism)
• Wound Healing
• Wounds and Injuries (genetics, metabolism, physiopathology)
• SS-B Antigen