Abstract | AIMS: The effects of chronic administration of Ferutinin ( phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS: The experimental study included 40 female Sprague-Dawley rats, assigned to two different protocols, i.e. preventive and recovering. In the preventive protocol, ferutinin (2mg/kg/day) was orally administered for 30days, starting from the day after ovariectomy; in the recovering protocol, ferutinin was administered, at the same dosage, for 30days starting from the 60th day after ovariectomy, when osteoporosis was clearly established. Its effects were compared with those of estradiol benzoate (1.5μg per rat twice a week, subcutaneously injected) vs. vehicle-treated ovariectomized controls and vehicle-treated sham-operated controls. Uteri were removed, weighed and analysed under both the structural and histomorphometrical points of view. KEY FINDINGS: SIGNIFICANCE:
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Authors | Marzia Ferretti, Laura Bertoni, Francesco Cavani, Marta Benincasa, Paola Sena, Gianluca Carnevale, Manuela Zavatti, Vittoria Di Viesti, Paola Zanoli, Carla Palumbo |
Journal | Life sciences
(Life Sci)
Vol. 90
Issue 3-4
Pg. 161-8
(Jan 16 2012)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 22100510
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Benzoates
- Bridged Bicyclo Compounds
- Cycloheptanes
- Sesquiterpenes
- 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en
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Topics |
- Animals
- Benzoates
(pharmacology, therapeutic use)
- Bone Density
(drug effects, physiology)
- Bridged Bicyclo Compounds
(pharmacology, therapeutic use)
- Cycloheptanes
(pharmacology, therapeutic use)
- Disease Models, Animal
- Drug Evaluation, Preclinical
(methods)
- Female
- Osteoporosis
(drug therapy, pathology)
- Ovariectomy
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Sesquiterpenes
(pharmacology, therapeutic use)
- Treatment Outcome
- Uterus
(drug effects, pathology)
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