Tomentosones A and B, hexacyclic phloroglucinol derivatives from the Thai shrub Rhodomyrtus tomentosa.

Abstract

Two phloroglucinols named tomentosones A and B (1 and 2) that each possess a novel hexacyclic ring system were isolated from the CH(2)Cl(2) extract of Rhodomyrtus tomentosa leaves. Their structures were elucidated from analyses of 2D NMR spectroscopic data. Tomentosone A inhibited the growth of chloroquine-resistant and -sensitive strains of the malaria parasite Plasmodium falciparum, with IC(50) values of 1.49 μM and 1.0 μM, respectively, while tomentosone B was significantly less active.

• Authors: Asadhawut Hiranrat, Wilawan Mahabusarakam, Anthony R Carroll, Sandra Duffy, Vicky M Avery
• Journal: The Journal of organic chemistry (J Org Chem) Vol. 77 Issue 1 Pg. 680-3 (Jan 06 2012) ISSN: 1520-6904 [Electronic] United States
• PMID: 22085112 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Plant Extracts
• tomentosone A
• tomentosone B
• Phloroglucinol

Topics

• Antimalarials (chemistry, isolation & purification, pharmacology)
• Inhibitory Concentration 50
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Phloroglucinol (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Plant Extracts (chemistry, isolation & purification, pharmacology)
• Plant Leaves
• Plasmodium falciparum (drug effects)