The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.

Abstract

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infectious pathogens.

• Authors: Pin-Yu Perera, Jack H Lichy, Thomas A Waldmann, Liyanage P Perera
• Journal: Microbes and infection (Microbes Infect) Vol. 14 Issue 3 Pg. 247-61 (Mar 2012) ISSN: 1769-714X [Electronic] France
• PMID: 22064066 (Publication Type: Journal Article, Review)
• Copyright: Published by Elsevier Masson SAS.

Chemical References

• Adjuvants, Immunologic
• Interleukin-15

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Dendritic Cells (immunology)
• Host-Pathogen Interactions
• Humans
• Immunity
• Inflammation (immunology)
• Interleukin-15 (immunology, therapeutic use)
• Killer Cells, Natural (immunology)
• Macrophages (immunology)
• Mast Cells (immunology)
• Monocytes (immunology)
• Mycobacterium tuberculosis (immunology, pathogenicity)
• Neutrophils (immunology)
• Signal Transduction
• T-Lymphocytes (immunology)
• Tuberculosis (immunology, microbiology)
• Virus Diseases (immunology, virology)
• Viruses (immunology, pathogenicity)