[Histological classification: evaluation of resection specimens of EMR/ESD--response evaluation after neoadjuvant therapy].

Abstract

The surveillance of patients with Barrett mucosa in the distal oesophagus leads to an increase of patients diagnosed with early cancer of the oesophagogastric junction and stomach with only superficial infiltration. Comparable to Asian countries where screening of patients at risk is recommended due to the high incidence of gastric cancer, endoscopic resection of early cancer in the stomach and distal oesophagus is increasing. In spite of the special endoscopic techniques--there are several requirements for the resected specimen which ensure its exact pathohistological evaluation. This is necessary to detect the exact depth of infiltration and the resection margins. To provide an exact pathohistological diagnosis is important for further therapeutic implications and prognosis. Advanced carcinomas of the oesophagus and stomach need multimodal treatment with radiation and chemotherapy. This has a special impact on the tumour which leads to pathohistological detectable changes as estimated in the so-called regression grading.

• Authors: J Munding, W Ziebarth, O Belyaev, W Uhl, A Tannapfel
• Journal: Zentralblatt fur Chirurgie (Zentralbl Chir) Vol. 138 Suppl 2 Pg. e55-62 (Dec 2013) ISSN: 1438-9592 [Electronic] Germany
• Vernacular Title: Histologische Klassifikation: Beurteilung von Resektaten nach EMR/ESD - Regressionsstadien nach präoperativer Vorbehandlung.
• PMID: 22025359 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Adenocarcinoma (classification, pathology, therapy)
• Barrett Esophagus (classification, pathology, therapy)
• Carcinoma, Squamous Cell (classification, pathology, therapy)
• Combined Modality Therapy
• Esophageal Neoplasms (classification, pathology, therapy)
• Esophagogastric Junction (pathology)
• Esophagoscopy
• Esophagus (pathology)
• Gastric Mucosa (pathology)
• Humans
• Neoadjuvant Therapy
• Neoplasm Grading
• Neoplasm Invasiveness
• Neoplasm Staging
• Precancerous Conditions (classification, pathology, therapy)
• Prognosis
• Stomach Neoplasms (pathology, surgery)