Abstract | BACKGROUND/AIM: METHODS: A prospective controlled study involving 67 infants with TTN and 33 controls ≥34 weeks gestational age was conducted. Study and control groups were compared for plasma NT-proBNP levels measured on the 6th, 24th, 72nd and 120th hours of life. Cardiac systolic functions were evaluated by echocardiography. RESULTS:
NT-proBNP levels were significantly higher in neonates with TTN compared to controls at 6th, 24th, 72nd and 120th hours (p<0.001). NT-proBNP levels at 24th and 72nd hours were significantly higher in infants with prolonged tachypnea (p=0.007 and p=0.03) and in those who required respiratory support (p=0.006 and p<0.001). Tachypnea duration was correlated with NT-proBNP levels at 24h (r=0.41, p=0.001). At a cut-off value of 6575 pg/ml, NT-proBNP had a sensitivity of 85% and specificity of 64% to predict mechanical ventilation requirement. Cardiac systolic functions were normal in all TTN patients. CONCLUSION:
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Authors | Ozge Aydemir, Cumhur Aydemir, Yusuf Unal Sarikabadayi, Nahide Altug, Omer Erdeve, Nurdan Uras, Serife Suna Oguz, Ugur Dilmen |
Journal | Early human development
(Early Hum Dev)
Vol. 88
Issue 5
Pg. 315-9
(May 2012)
ISSN: 1872-6232 [Electronic] Ireland |
PMID | 21955499
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Biomarkers
(blood)
- Birth Weight
- Female
- Gestational Age
- Humans
- Infant, Newborn
- Male
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Transient Tachypnea of the Newborn
(blood, diagnosis)
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