Molecular profile of oligodendrogliomas in young patients.

Abstract

Several studies on molecular profiling of oligodendrogliomas (OGs) in adults have shown a distinctive genetic pattern characterized by combined deletions of chromosome arms 1p and 19q, O6-methylguanine-methyltransferase (MGMT) methylation, and isocitrate dehydrogenase 1 (IDH1) mutation, which have potential diagnostic, prognostic, and even therapeutic relevance. OGs in pediatric and young adult patients are rare and have been poorly characterized on a molecular and biological basis, and it remains uncertain whether markers with prognostic significance in adults also have predictive value in these patients. Fourteen cases of OGs in young patients (age, ≤ 25 years) who received a diagnosis over 7 years were selected (7 pediatric patients age ≤ 18 years and 7 young adults aged 19-25 years). The cases were evaluated for 1p/19q status, MGMT promoter methylation, p53 mutation, and IDH1 mutation. None of the pediatric cases showed 1p/19q deletion. In young adults, combined 1p/19q loss was observed in 57% and isolated 1p loss in 14% of cases. The majority of cases in both subgroups (71% in each) harbored MGMT gene promoter methylation. TP53 and IDH1 mutations were not seen in any of the cases in both the groups. To our knowledge, this is the first study to show that molecular profile of OGs in pediatric and young adult patients is distinct. Further large-scale studies are required to identify additional clinically relevant genetic alterations in this group of patients.

• Authors: Vaishali Suri, Prerana Jha, Shipra Agarwal, Pankaj Pathak, Mehar Chand Sharma, Vikas Sharma, Sudhanshu Shukla, Kumaravel Somasundaram, Ashok Kumar Mahapatra, Shashank Sharad Kale, Chitra Sarkar
• Journal: Neuro-oncology (Neuro Oncol) Vol. 13 Issue 10 Pg. 1099-106 (Oct 2011) ISSN: 1523-5866 [Electronic] England
• PMID: 21937591 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tumor Suppressor Protein p53
• Tumor Suppressor Proteins
• Isocitrate Dehydrogenase
• IDH1 protein, human
• DNA Modification Methylases
• MGMT protein, human
• DNA Repair Enzymes

Topics

• Adolescent
• Brain Neoplasms (genetics)
• Child
• Child, Preschool
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 19 (genetics)
• DNA Methylation
• DNA Modification Methylases (genetics)
• DNA Mutational Analysis
• DNA Repair Enzymes (genetics)
• Female
• Humans
• Isocitrate Dehydrogenase (genetics)
• Male
• Mutation
• Oligodendroglioma (genetics)
• Polymerase Chain Reaction
• Prognosis
• Promoter Regions, Genetic (genetics)
• Tumor Suppressor Protein p53 (genetics)
• Tumor Suppressor Proteins (genetics)
• Young Adult