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Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Also Known As:
Isocitrate Dehydrogenase (NAD+); Dehydrogenase, Isocitrate; Isocitrate Dehydrogenase-I; Dehydrogenase, NAD Isocitrate; Isocitrate Dehydrogenase I; Isocitrate Dehydrogenase, NAD; NAD Isocitrate Dehydrogenase; Isocitrate:NAD+ oxidoreductase (decarboxylating)
Networked: 2705 relevant articles (48 outcomes, 223 trials/studies)

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Experts

1. von Deimling, Andreas: 55 articles (05/2022 - 12/2008)
2. Wick, Wolfgang: 47 articles (05/2022 - 10/2009)
3. Weller, Michael: 43 articles (01/2022 - 10/2009)
4. Reifenberger, Guido: 36 articles (06/2022 - 10/2009)
5. Cahill, Daniel P: 27 articles (01/2022 - 08/2012)
6. Herold-Mende, Christel: 24 articles (01/2022 - 10/2009)
7. Yan, Hai: 24 articles (10/2021 - 02/2009)
8. Lai, Albert: 23 articles (05/2022 - 05/2011)
9. Kato, Yukinari: 23 articles (06/2019 - 12/2009)
10. Jiang, Tao: 22 articles (06/2022 - 01/2014)

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