Abstract | OBJECTIVE: METHODS: RESULTS:
Pravastatin had no effect on fasting insulin and HOMA-IR but significantly reduced plasma NEFA and glycerol levels and increased glucose infusion rate (GIR) during the hyperinsulinemic clamp. Increase in GIR induced by pravastatin was not abolished by NO synthase inhibitor, l-NAME, indicating that this effect did not result from the improvement of endothelial function. Atorvastatin increased fasting insulin, HOM-IR, NEFA and glycerol levels as well as reduced GIR. Statins had no effect on leptin, HMW adiponectin, resistin, visfatin, interleukin-6 and TNF-α. Pravastatin increased plasma concentrations of 25-hydroxy- and 1,25-dyhydroxyvitamin D(3) (25-OH-D(3) and 1,25-(OH)(2)-D(3)), and its effect on insulin sensitivity was mimicked by exogenous 1,25-(OH)(2)-D(3). Atorvastatin reduced plasma 25-OH-D(3) but had no effect on 1,25-(OH)(2)-D(3). Decrease in insulin sensitivity induced by atorvastatin was not corrected by supplementation of vitamin D(3) despite normalization of plasma 25-OH-D(3) level. CONCLUSIONS:
|
Authors | Jerzy Bełtowski, Pepa Atanassova, George N Chaldakov, Anna Jamroz-Wiśniewska, Wojciech Kula, Marta Rusek |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 219
Issue 2
Pg. 526-31
(Dec 2011)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 21889144
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Adipokines
- Biomarkers
- Blood Glucose
- Fatty Acids, Nonesterified
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Inflammation Mediators
- Insulin
- Pyrroles
- Cholecalciferol
- Atorvastatin
- Calcitriol
- Pravastatin
- Calcifediol
- Glycerol
|
Topics |
- Adipokines
(blood)
- Adipose Tissue
(drug effects, metabolism)
- Animals
- Atorvastatin
- Biomarkers
(blood)
- Blood Glucose
(drug effects, metabolism)
- Calcifediol
(blood, pharmacology)
- Calcitriol
(blood, pharmacology)
- Cholecalciferol
(blood, pharmacology)
- Fasting
(blood)
- Fatty Acids, Nonesterified
(blood)
- Glucose Clamp Technique
- Glycerol
(blood)
- Heptanoic Acids
(pharmacology)
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Inflammation Mediators
(blood)
- Insulin
(blood)
- Insulin Resistance
- Liver
(drug effects, metabolism)
- Male
- Muscle, Skeletal
(drug effects, metabolism)
- Pravastatin
(pharmacology)
- Pyrroles
(pharmacology)
- Rats
- Rats, Wistar
- Time Factors
|