Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.

Abstract

OBJECTIVE:

To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.

METHODS:

One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.

RESULTS:

The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).

CONCLUSION:

Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.

• Authors: Ali Movafegh, Laleh Eslamian, Azita Dorabadi
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 115 Issue 3 Pg. 224-6 (Dec 2011) ISSN: 1879-3479 [Electronic] United States
• PMID: 21872857 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antifibrinolytic Agents
• Oxytocics
• Oxytocin
• Tranexamic Acid

Topics

• Adult
• Antifibrinolytic Agents (therapeutic use)
• Blood Loss, Surgical (prevention & control)
• Cesarean Section (adverse effects, methods)
• Double-Blind Method
• Female
• Humans
• Infusions, Intravenous
• Oxytocics (administration & dosage)
• Oxytocin (administration & dosage)
• Postpartum Hemorrhage (etiology, prevention & control)
• Tranexamic Acid (therapeutic use)
• Uterine Hemorrhage (etiology, prevention & control)
• Young Adult