Postoperative Hemorrhage

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807 relevant articles (54 outcomes, 66 trials/studies) found for this Disease

Description: Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.

Also Known As:

Hemorrhages, Postoperative; Postoperative Hemorrhages; Loss, Postoperative Blood; Postoperative Blood Loss; Blood Loss, Postoperative; Hemorrhage, Postoperative

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Hemorrhage: 53419

Postoperative Hemorrhage: 807

Postoperative Complications

Postoperative Hemorrhage: 807

Related Diseases

1.	Heart Diseases (Heart Disease)
2.	Postoperative Hemorrhage
3.	Hemorrhage
4.	Pain (Aches)
5.	Myocardial Infarction

Experts

1.	Durand, M: 2 articles (01/2006 - 06/2002)
2.	Chavanon, O: 2 articles (01/2006 - 06/2002)
3.	Raabe, Andreas: 2 articles (11/2003 - 06/2002)
4.	Seifert, Volker: 2 articles (11/2003 - 06/2002)
5.	Gerlach, Rüdiger: 2 articles (11/2003 - 06/2002)
6.	Piper, Swen N: 1 article (08/2008)
7.	Suttner, Stefan W: 1 article (08/2008)
8.	Crawford, James V: 1 article (08/2008)
9.	Demars, Sean M: 1 article (08/2008)
10.	Harsha, Wayne J: 1 article (08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postoperative Hemorrhage:

1.	Aprotinin (Trasylol)FDA Link 09/01/1999 - "Although administered intraoperatively, aprotinin treatment dramatically reduced intraoperative and 24-h postoperative blood loss and autologous transfusion requirements but did not change homologous transfusion in posterior lumbar spine fusion. " 06/01/2004 - "Full-dose aprotinin significantly reduces postoperative blood loss and has been demonstrated in multiple prospective blinded studies to be safe and effective. " 03/01/2001 - "RESULTS: A significant reduction in postoperative blood loss (approximately 470 ml) occurred in patients receiving aprotinin. " 08/01/1994 - "CONCLUSIONS: Aprotinin inhibited fibrinolysis; this correlated with a significant reduction of postoperative blood loss and need for blood replacement after CPB. " 09/01/2004 - "More recently, aprotinin topically applied in the pericardial cavity was also found to improve postoperative blood loss. " Order ALL the reference details at left...
2.	Tranexamic Acid (AMCA)FDA Link 04/01/2004 - "Regarding time-related changes of postoperative blood loss, significant reduction was observed during the first 2 h after surgery in the tranexamic acid group ( P<0.001). " 07/01/1993 - "The authors thus conclude that antifibrinolytic therapy during CPB with tranexamic acid reduces postoperative blood loss, and shortens the operation time due to an improvement in hemostasis." 06/01/2009 - "Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). " 08/01/2007 - "Postoperative blood loss was significantly less in the tranexamic acid group compared to the control group (320 +/- 38 vs 480 +/- 75 mL). " 08/01/2005 - "There are conflicting results in the literature about tranexamic acid (TA) infusion in reducing postoperative blood loss and the number of transfused red cells (RBC) units. " Order ALL the reference details at left...
3.	Heparin (Liquaemin)FDA LinkGeneric 03/01/2009 - "Using the Hemochron RxDx, we observed a significant reduction in postoperative blood loss, as well as the amount of heparin and initial doses of protamine used during CPB. " 02/01/2008 - "Although the HC group received significantly greater amounts of heparin, this did not reduce hemostatic activation, postoperative blood loss, or transfusion requirements. " 08/01/1977 - "The protamine/heparin ratio was 25% less in Group II compared with Group I, and the 12-hour postoperative blood loss was 48% less in Group II. The automated ACT is a reliable, rapid, and simple test that has resulted in improved hemostasis following cardiac operation." 10/01/2005 - "CONCLUSIONS: Although mechanical prophylaxis provided effective prophylaxis against DVT/PE in many series, the added efficacy of low-dose heparin regimens has to be weighed against risks of major postoperative hemorrhages and their neurological sequelae." 12/01/2003 - "In recent years, increasing numbers of studies are proving significant reductions in postoperative blood loss and transfusion requirements and improvements in clinical outcomes as a result of heparin-coated circuits. " Order ALL the reference details at left...
4.	6-Aminocaproic Acid (6 Aminocaproic Acid)FDA LinkGeneric 02/01/2000 - "We have studied the efficacy of epsilon aminocaproic acid in reducing postoperative blood loss in infants and children with congenital cyanotic cardiac anomalies undergoing corrective operative procedures. " 02/01/2000 - "Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss." 06/01/2002 - "OBJECTIVE: To determine if the use of an antifibrinolytic agent (epsilon aminocaproic acid [EACA]) decreased perioperative and postoperative blood loss in patients who underwent total hip arthroplasty (THA). " 11/01/1963 - "[THERAPY OF POSTOPERATIVE HEMORRHAGE FOLLOWING PROSTATECTOMY WITH SPECIAL REFERENCE TO THE EFFECT OF 6-AMINOCAPROIC ACID.]" 02/01/2000 - "It was found that epsilon aminocaproic acid is effective in reducing postoperative blood loss, packed red cells and plasma product requirements in paediatric patients undergoing corrective surgical procedures for congenital cyanotic heart diseases." Order ALL the reference details at left...
5.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 06/01/1991 - "Following two early promising reports that treatment with intravenous DDAVP was helpful in reducing postoperative hemorrhage and the amount of transfusion with homologous blood products in patients who had undergone cardiac surgery with CPB, these results were not repeated in any of the follow-up studies. " 10/01/1995 - "In contrast, in trials in which the mean blood loss in placebo-treated patients fell in the upper third of distribution (> 1109 ml/24 h), desmopressin significantly decreased postoperative blood loss by 34%. " 10/01/1995 - "The effect of desmopressin (DDAVP) on reducing postoperative blood loss after cardiac surgery has been studied in several randomized clinical trials with conflicting outcomes. " 12/01/1996 - "CONCLUSIONS: Activated clotting time-based clot ratio values correlate significantly with postoperative blood loss and detect recovery of PAF-accelerated coagulation after administration of DDAVP or platelet therapy. " 10/01/1995 - "Desmopressin significantly reduced postoperative blood loss by 9%, but had no statistically significant effect on transfusion requirements. " Order ALL the reference details at left...
6.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 08/01/1982 - "In the fibrin glue group there was a significant reduction in postoperative blood loss as well as a shortening of the operation time (period of protamin administration to skin closure). " 10/01/1981 - "In the fibrin glue group there was a significant reduction in postoperative blood loss as well as a shortening of the operation time (period of protamin administration to skin closure). " 07/01/2007 - "To counteract these effects we investigated whether the use of autologous derived platelet gel and fibrin sealant would reduce postoperative blood loss, decrease the impaired range of motion and the incidence of arthrofibrosis. " 11/01/1999 - "RESULTS: The mean apparent postoperative blood loss (and standard deviation) in the fibrin-tissue-adhesive group was 360+/-287.7 milliliters compared with 878+/-403.0 milliliters in the control group, with a mean difference of 518 milliliters (p<0.001). " 02/01/1989 - "Fibrin sealant reduces postoperative blood loss and decreases the incidence of emergency resternotomy. " Order ALL the reference details at left...
7.	Aminocaproic Acids (EAC)FDA LinkGeneric 12/01/1998 - "The results of this study support the notion that early identification and treatment of HRP with ATIII and aminocaproic acid may decrease postoperative blood loss." 11/01/1964 - "[Postoperative hemorrhage in gynecology treated with hemocaprol]" 04/01/2004 - "CONCLUSION: Aminocaproic acid and tranexamic acid are equally effective in reducing postoperative blood loss, as well as blood and blood product requirements in children with cyanotic heart disease undergoing corrective surgery as compared with the control group." 04/01/2004 - "OBJECTIVE: This study compared the efficacy of aminocaproic acid and tranexamic acid in reducing postoperative blood loss, as well as blood and blood product requirements in children with cyanotic congenital heart disease. " 02/01/1999 - "High dose aprotinin significantly reduces postoperative blood loss compared with aminocaproic acid and desmopressin, and decreases transfusion requirements compared with desmopressin. " Order ALL the reference details at left...
8.	Kallikreins (Kallikrein)IBA 09/01/2008 - "BACKGROUND: In the present study we assessed whether aprotinin at a total dose (40,000 kallikrein inhibitor units (KIU)/kg) is effective in reducing postoperative blood loss and blood product requirement after arterial switch operations in infants. " 12/01/1992 - "The effect on postoperative blood loss and blood use of blood-saving treatment with or without 280 mg of low-dose aprotinin (2 million kallikrein inactivator units) was studied in 200 consecutive patients undergoing either unilateral or bilateral internal mammary artery bypass grafting. " 09/01/1994 - "Intra- and postoperative blood loss during open heart surgery is reduced by approximately 50% when aprotinin, a potent inhibitor for plasmin and kallikrein, is administered during surgery. " Order ALL the reference details at left...
9.	TeaIBA 04/01/1997 - "The efficacy of TEA was studied in an unblinded study using historical controls by comparing the postoperative blood loss and the transfusion requirements of red blood cells (RBC) in patient groups treated without (n = 9) and with TEA (n = 10). " 04/01/1997 - "Based on the authors' experience they conclude: (1) TEA is effective in reducing postoperative blood loss, hemorrhagic complications, and RBC transfusion requirements associated with CDH repair on ECMO. " 06/01/1990 - "Colonic surgery patients were studied to measure: the influence of continuous thoracic epidural analgesia (TEA) on a postoperative pain score, the time till onset of defaecation, blood loss, postoperative temperature elevations, rate of bacterial contamination of wounds and urine, and general surgical complications. " Order ALL the reference details at left...
10.	Diatomaceous Earth (Kieselguhr)IBA 07/01/1979 - "A significant difference was seen in the measured heparin levels (p less than 0.01, Celite ACT (p less than 0.01), and BART (p less than 0.01) in patients on Protocols I and II. Ten of the 24 patients on Protocol I and none on Protocol II showed heparin rebound phenomenon, and blood loss in patients on Protocol I was significantly greater than that in patients on Protocol II. The study clearly demonstrates that our protocol of heparin administration and control with simpler tests ensures safe hypocoagulation during ECC and efficient reversal at the end, with minimal postoperative blood loss." Order ALL the reference details at left...

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 04/01/2003 - "The aim of this prospective randomized study was to compare the effects of the transfusion of unprocessed and cell saver-processed residual cardiopulmonary bypass (CPB) volume on haemostasis, complement activation, postoperative blood loss and transfusion requirements after elective cardiac surgery. " 01/01/2002 - "OBJECTIVE: The aim of this study was to evaluate the effect of autologous centrifuged residual cardiopulmonary bypass blood on patients' hematocryte value, donor blood product requirements, postoperative blood loss, hospitalization time and the development of infective complications. " 04/01/2001 - "A prospective randomized study was designed to investigate the effect of coronary bypass with or without cardiopulmonary bypass on postoperative blood loss and transfusion requirement. " 02/01/2008 - "OBJECTIVE: The inadequacy of heparinization during cardiopulmonary bypass (CPB) can lead to hemostatic activation with increases in postoperative blood loss and blood product requirements after cardiac surgery. " 01/01/2007 - "Impact of Sonoclot hemostasis analysis after cardiopulmonary bypass on postoperative hemorrhage in cardiac surgery." Order ALL the reference details at left...
2.	Blood Transfusion (Blood Transfusions) 08/01/1992 - "In the Study Group, there was a reduction in the amount of homologous blood transfusion, intraoperatively as well as totally, and also in postoperative blood loss in all three operation subsets. " 03/01/1985 - "The study revealed no significant differences in estimated intraoperative blood loss, postoperative hemovac drainage, total amount of blood transfusion, intra- or postoperative complications, or postoperative functional results in the two groups. " 10/01/2009 - "We compared blood loss, number of transfusions, postoperative complications and knee function and found significantly less postoperative blood loss through the drains (p < 0.001), and fewer blood transfusions (p = 0.09) were needed in the clamped group. " 09/01/2009 - "The risk of experiencing a postoperative complication (including death) (P < .0001), returning to operating room for reexploration (P < .0001), staying in intensive care unit for longer than 72 hours (P < .0001), receiving ventilation for longer than 24 hours (P < .0001), and receiving any kind of postoperative blood transfusion (P < .0001) was significantly higher in patients with excessive postoperative hemorrhage. " 07/01/2009 - "Predefined secondary endpoints were postoperative blood loss, blood transfusions, haemoglobin levels 24 hours (h) after surgery, and global haemostasis assessed with thromboelastometry, 2 and 24 hours after surgery. " Order ALL the reference details at left...
3.	Chest Tubes (Chest Tube) 05/01/2000 - "Primary outcome measures in this study were total volume of blood loss (postoperative chest tube drainage) and volume of transfusions during hospitalization. " 09/01/2008 - "Postoperative blood loss through the thoracic chest tubes and blood product requirements (mL/kg/24 h) were measured for the first 24 h in the intensive care unit. " 05/01/2004 - "MEASUREMENTS AND MAIN RESULTS: Postoperative blood loss was estimated from the volume of chest tube drainage. " 07/01/2001 - "Postoperative blood loss was defined as the chest tube drainage during the first 24 h after surgery. " 04/01/2001 - "Postoperative blood loss identified as total chest tube drainage, transfusion requirement, and related costs together with hematologic indices and clotting profiles were analyzed. " Order ALL the reference details at left...
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/01/1988 - "After conducting an initial study concerning the fate of platelets during CPB, in which we determined that PGI(2) had a protective effect, we investigated the effects of PGI(2) infusion during CPB on postoperative blood loss in 554 open-heart surgery patients, 200 of whom underwent valve replacement, 200 of whom had coronary artery bypass grafting (CABG), and 154 of whom underwent repeat valve replacement or CABG. " 02/01/2009 - "Preoperative platelet inhibition with ASA does not influence postoperative blood loss following coronary artery bypass grafting." 06/01/2001 - "In conclusion, MUF is useful to hemoconcentrate and reduce postoperative blood loss in coronary artery bypass grafting." 08/01/2000 - "Prostaglandin E(1) does not influence plasmatic coagulation, hepatic synthesis, or postoperative blood loss in patients after coronary-artery bypass grafting." 04/01/2001 - "CONCLUSIONS: Coronary artery bypass grafting on the beating heart is associated with a significant reduction in postoperative blood loss, transfusion requirement, and transfusion-related cost when compared with conventional revascularization with cardiopulmonary bypass and cardioplegic arrest." Order ALL the reference details at left...
5.	Arthroplasty 01/01/2006 - "The results show that delaying release of the drains by one hour reduces postoperative blood loss and transfusion requirement following total knee arthroplasty." 10/01/2005 - "These results suggested that clamping the drainage in the first 4 postoperative hours reduces postoperative blood loss without causing excess morbidity after total knee arthroplasty." 07/01/2005 - "CONCLUSION: The method of 2-hourly clamping of drain and release for 10 min significantly reduces postoperative blood loss, without any added increase of complication, after total knee arthroplasty." 10/01/2000 - "Plugging the intramedullary canal of the femur in total knee arthroplasty: reduction in postoperative blood loss." 01/01/2000 - "There have been several attempts to reduce postoperative blood loss in patients undergoing total arthroplasty. " Order ALL the reference details at left...

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