Abstract | BACKGROUND: METHODS AND MATERIALS: We performed overview of the literature based on database searches in PubMed/MEDLINE and we included articles till December 2010. Only papers published in English were included. RESULTS: There was no standard fractionation regimen: some physicians prescribed high doses, such as the ones of invasive skin cancer, whereas others prescribed lower doses because of the noninvasive nature of the disease, the sensitive anatomic location (e.g., extremity) and the large treatment area. Various studies demonstrate high rates of tumor control with minimal morbidity following definitive radiation therapy in the treatment of Bowen's Disease. Through a multidisciplinary assessment, the treatment of Bowen's disease can be individualized to optimize patient care. CONCLUSIONS:
Radiation therapy is an effective treatment option for Bowen's disease of the skin. Local recurrences seem to be equally low in patients treated with high- and low-dose regimens. Radiotherapy preserves normal tissues ensuring a superior esthetic and functional outcome.
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Authors | Zygogianni Anna, Kouvaris John, Tolia Maria, Kyrgias George, Beli Ivelina, Kantzou Ioanna, Soulimioti Georgia, Kouloulias Vassilis |
Journal | Reviews on recent clinical trials
(Rev Recent Clin Trials)
Vol. 7
Issue 1
Pg. 42-6
(Feb 2012)
ISSN: 1876-1038 [Electronic] United Arab Emirates |
PMID | 21864250
(Publication Type: Journal Article, Review)
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Topics |
- Bowen's Disease
(radiotherapy)
- Humans
- Skin Neoplasms
(radiotherapy)
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