Abstract | PURPOSE: Overconsumption of sugar-sweetened beverages, in particular carbonated soft drinks, promotes the development of overweight and obesity and is associated with metabolic disturbances, including intrahepatic fat accumulation and metabolic syndrome. One theory proposes that drinks sweetened with high-fructose corn syrup are particularly detrimental to health, as they contain fructose in its 'free' monosaccharide form. This experiment tested whether consuming 'free' fructose had a greater impact on body weight and metabolic abnormalities than when consumed 'bound' within the disaccharide sucrose. METHODS: Male Hooded Wistar rats were given free access for 56 days to 10% sucrose (Group Suc), 10%, 50/50 fructose/ glucose (Group FrucGluc) or water control drinks (Group Control), plus chow. Caloric intake and body weights were measured throughout the protocol, and the following metabolic indices were determined between days 54 and 56: serum triglycerides, liver triglycerides, retroperitoneal fat and oral glucose tolerance. RESULTS: Animals with access to sugar beverages consumed 20% more calories, but did not show greater weight gain than controls. Nevertheless, they developed larger abdominal fat pads, higher triglyceride levels and exhibited impaired insulin/ glucose homeostasis. Comparison of the two sugars revealed increased fasting glycaemia in the FrucGluc group, but not in Suc group, whereas the Suc group was more active in an open field. CONCLUSIONS:
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Authors | Anastasia Sheludiakova, Kieron Rooney, Robert A Boakes |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 51
Issue 4
Pg. 445-54
(Jun 2012)
ISSN: 1436-6215 [Electronic] Germany |
PMID | 21800086
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dietary Sucrose
- Triglycerides
- Fructose
- Glucose
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Topics |
- Adiposity
- Animals
- Behavior, Animal
- Beverages
(adverse effects)
- Carbonated Beverages
(adverse effects)
- Dietary Sucrose
(administration & dosage, adverse effects)
- Female
- Fructose
(administration & dosage, adverse effects)
- Glucose
(administration & dosage, adverse effects)
- Hyperglycemia
(etiology)
- Hyperphagia
(etiology, metabolism, pathology, physiopathology)
- Insulin Resistance
- Intra-Abdominal Fat
(pathology)
- Liver
(metabolism)
- Male
- Metabolic Syndrome
(etiology)
- Motor Activity
- Rats
- Rats, Wistar
- Triglycerides
(blood, metabolism)
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