Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.

Abstract

Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.

• Authors: Ming-Hui Yang, Pei-Yu Chu, Sharon Chia-Ju Chen, Tze-Wen Chung, Wen-Cheng Chen, Lia-Beng Tan, Wei-Chih Kan, Hsien-Yi Wang, Shih-Bin Su, Yu-Chang Tyan
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 411 Issue 4 Pg. 714-20 (Aug 12 2011) ISSN: 1090-2104 [Electronic] United States
• PMID: 21782798 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Proteome
• ADAM Proteins
• ADAM28 protein, human
• Arsenic

Topics

• ADAM Proteins (metabolism, urine)
• Aged
• Aged, 80 and over
• Amino Acid Sequence
• Arsenic (urine)
• Biomarkers, Tumor (metabolism)
• Blotting, Western
• Carcinoma, Transitional Cell (metabolism, pathology, urine)
• Female
• Humans
• Male
• Middle Aged
• Molecular Sequence Data
• Proteome (metabolism)
• Proteomics
• Urinary Bladder Neoplasms (metabolism, pathology, urine)