Potential role of nuclear factor κB in diabetic cardiomyopathy.

Abstract

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

• Authors: O Lorenzo, B Picatoste, S Ares-Carrasco, E Ramírez, J Egido, J Tuñón
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2011 Pg. 652097 ( 2011) ISSN: 1466-1861 [Electronic] United States
• PMID: 21772665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• NF-kappa B

Topics

• Apoptosis (physiology)
• Diabetic Cardiomyopathies (metabolism, therapy)
• Endothelium (physiopathology)
• Gene Expression Regulation
• Humans
• Inflammation (metabolism)
• Myocardium (metabolism, pathology)
• NF-kappa B (metabolism)
• Oxidative Stress (physiology)
• Signal Transduction (physiology)