Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance.

Abstract

OBJECTIVE:

To investigate the relation of circulating four adipokines (apelin, vaspin, visfatin, adiponectin) with markers of insulin sensitivity in large for gestational age (LGA) infants.

PATIENTS AND METHODS:

Forty LGA infants (20 LGA born from diabetic mothers and 20 LGA born from non-diabetic mothers) and 34 appropriate for gestational age (AGA) infants were recruited. Hyperinsulinism and insulin resistance was evaluated using the homeostasis model assessment (HOMA-IR), fasting glucose-to-insulin ratio (FGIR), quantitative insulin-sensitivity check index (QUICK-I) from fasting samples. Plasma adiponectin and vaspin levels were determined by radioimmunoassay. Determination of visfatin and apelin levels was performed by enzyme immunoassay.

RESULTS:

HOMA-IR, apelin and visfatin levels (p<0.001, p<0.001, p<0.001, respectively) were significantly elevated and adiponectin levels, FGIR and QUICK-I values. (p<0.001, p<0.001, p<0.05, respectively) were significantly lower in the LGA group. Vaspin levels were higher in the LGA group than AGA neonates without a significance. The LGA infants with diabetic mother had significantly higher visfatin, apelin, HOMA-IR values, fasting insulin levels and significantly lower adiponectin, FGIR, QUICK-I values. Apelin and visfatin were correlated positively, and adiponectin was correlated negatively with birthweight, HOMA-IR values and fasting insulin levels.

CONCLUSION:

Based on the findings of this study, it is too difficult to explain relation between birthweight and these adipocytokines, but findings of high insulin, HOMA-IR, visfatin, apelin and low adiponectin levels in the LGA neonates showed that these adipocytokines can be used as a good predictor for metabolic syndrome.

• Authors: Ferhat Cekmez, Fuat Emre Canpolat, Ozgur Pirgon, Merih Çetinkaya, Secil Aydinoz, Selami Suleymanoglu, Osman Metin Ipcioglu, Serdar Umit Sarici
• Journal: Cytokine (Cytokine) Vol. 56 Issue 2 Pg. 387-91 (Nov 2011) ISSN: 1096-0023 [Electronic] England
• PMID: 21742512 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• APLN protein, human
• Adiponectin
• Apelin
• Intercellular Signaling Peptides and Proteins
• SERPINA12 protein, human
• Serpins
• Nicotinamide Phosphoribosyltransferase

Topics

• Adiponectin (blood)
• Apelin
• Female
• Humans
• Infant, Newborn
• Insulin Resistance
• Intercellular Signaling Peptides and Proteins (blood)
• Male
• Nicotinamide Phosphoribosyltransferase (blood)
• Serpins (blood)