Abstract | BACKGROUND/AIMS: METHODS: Ten-week-old high IgA ddY mice were fed diets containing either perilla seed oil (PS group) or corn oil (C group, control). After 20 weeks, we compared body weight, blood pressure, serum creatinine levels, IgA levels, fatty acid composition, urinary protein excretion, mesangial matrix expansion, and glomerular transforming growth factor-β1 mRNA expression between groups. RESULTS: Serum n-3 PUFA levels were higher in the PS group than the C group (p<0.001). Blood urea nitrogen levels were lower (p=0.0246) and urinary protein excretion was reduced (p=0.0198) in the PS group. Mesangial matrix expansion (p=0.0063) and glomerular transforming growth factor-β1 mRNA expression (p=0.0291) were suppressed in the PS group. No significant differences between groups were found in body weight, blood pressure, serum IgA, and creatinine levels. CONCLUSIONS:
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Authors | Kaoru Sakurai, Koichi Asahi, Yoshinobu Kanesaki, Yoshimitsu Hayashi, Jun Asai, Toshiki Yuza, Kimio Watanabe, Tetsuo Katoh, Tsuyoshi Watanabe |
Journal | Nephron. Experimental nephrology
(Nephron Exp Nephrol)
Vol. 119
Issue 2
Pg. e33-9
( 2011)
ISSN: 1660-2129 [Electronic] Switzerland |
PMID | 21734409
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Dietary Fats
- Fatty Acids, Omega-3
- Plant Oils
- alpha-Linolenic Acid
- perilla seed oil
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Topics |
- Animals
- Dietary Fats
(therapeutic use)
- Fatty Acids, Omega-3
(blood)
- Glomerulonephritis, IGA
(diet therapy, pathology)
- Mice
- Plant Oils
(therapeutic use)
- alpha-Linolenic Acid
(blood, therapeutic use)
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