Abstract | PURPOSE: DESIGN: Retrospective case-control study. METHODS: SETTING: Tokyo Women's Medical University and Eguchi Eye Hospital. PATIENT POPULATION: OBSERVATION PROCEDURES: MAIN OUTCOME MEASURES: Vitreous fluid levels of the 3 molecules and severity of macular edema. RESULTS: BRVO patients had a significantly higher vitreous fluid level of sVEGFR-2 (median, 1670 pg/mL; interquartile range [IQL], 1205 to 2225 pg/mL) than macular hole patients (median, 1265 pg/mL; IQR, 731 to 1800 pg/mL; P = .017), as was the case for VEGF (median, 237 pg/mL; IQR, 42.2 to 1305 pg/mL; vs median, 15.6 pg/mL; IQR, 15.6 to 15.6 pg/mL; P < .001) and sICAM-1 (median, 10.1 ng/mL; IQR, 6.3 to 22.5 ng/mL; vs median, 4.1 ng/mL; IQR, 3.3 to 6.0 ng/mL; P < .001). In BRVO patients, there was a significant positive correlation between vitreous fluid levels of sVEGFR-2 or VEGF and sICAM-1, but not between sVEGFR-2 and VEGF. Vitreous fluid levels of all 3 molecules were correlated significantly the with severity of macular edema in BRVO patients. CONCLUSIONS: sVEGFR-2 may induce an increase of vascular permeability together with or via sICAM-1, or both with and via sICAM-1, in BRVO patients with macular edema.
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Authors | Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Shuichiro Eguchi, Sadao Hori |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 152
Issue 4
Pg. 669-677.e1
(Oct 2011)
ISSN: 1879-1891 [Electronic] United States |
PMID | 21726846
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Intercellular Adhesion Molecule-1
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Aged
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescein Angiography
- Humans
- Intercellular Adhesion Molecule-1
(metabolism)
- Laser Coagulation
- Macular Edema
(diagnosis, metabolism, surgery)
- Male
- Retinal Perforations
(metabolism)
- Retinal Vein Occlusion
(diagnosis, metabolism)
- Retrospective Studies
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor A
(metabolism)
- Vascular Endothelial Growth Factor Receptor-2
(metabolism)
- Vitrectomy
- Vitreous Body
(metabolism)
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