Immunogenicity of the reduced-antigen-content dTpa vaccine (Boostrix(®)) in adults 55 years of age and over: a sub-analysis of four trials.

Abstract

BACKGROUND:

Older adults, especially those over 65 years, are at risk of more severe morbidity from diphtheria, tetanus and pertussis and may transmit pertussis to unvaccinated or not yet fully vaccinated infants, but data on their response to reduced-antigen-content tetanus, diphtheria and acellular pertussis (dTpa) vaccines are lacking.

METHODS:

A sub-analysis pooled immunogenicity results in 293 adults aged 55+ years (mean age 64.4 years) from four randomised, controlled clinical trials of dTpa vaccine (Boostrix(®), GlaxoSmithKline Biologicals) with or without IPV co-administration, or dTpa-IPV (Boostrix(®) IPV).

RESULTS:

Seroprotective antibody levels were achieved by 82.8% for diphtheria and 94.5% for tetanus. For pertussis antigens, the booster response rate, defined as initially seronegative subjects [<5EU/mL] reaching ≥5EU/mL; or a ≥2-fold increase in antibody concentration if initially seropositive was 89.2% for pertussis toxoid, 95.8% for filamentous haemagglutinin and 94.5% for pertactin. Post-booster geometric mean concentrations (GMC) increased for all antigens. Post-booster anti-tetanus and anti-PRN GMCs tended to be higher in 55- to 64-year olds than in those aged 65+.

CONCLUSION:

Larger numbers of subjects over 75 years are needed to better define responses in advanced age, but these data suggest that a single booster dose of dTpa or dTpa-IPV induces good immunological responses in most, and that these vaccines could be readily integrated into existing programmes.

• Authors: Pierre Van Damme, Peter McIntyre, Emmanuel Grimprel, Sherine Kuriyakose, Jeanne-Marie Jacquet, Karin Hardt, Marc Messier, Olivier Van Der Meeren
• Journal: Vaccine (Vaccine) Vol. 29 Issue 35 Pg. 5932-9 (Aug 11 2011) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 21718738 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Boostrix
• Diphtheria-Tetanus-Pertussis Vaccine
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Vaccines, Inactivated

Topics

• Aged
• Aged, 80 and over
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (blood, immunology)
• Diphtheria (immunology, prevention & control)
• Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage, adverse effects, immunology)
• Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage, adverse effects, immunology)
• Female
• Humans
• Immunization, Secondary
• Male
• Middle Aged
• Tetanus (immunology, prevention & control)
• Treatment Outcome
• Vaccines, Inactivated (administration & dosage, adverse effects, immunology)
• Whooping Cough (immunology, prevention & control)