Abstract | AIM: METHODS: Liver cirrhosis was induced in Sprague-Dawley rats by bile duct ligation (BDL). In addition, splenectomy and administration of ketanserin, which selectively antagonizes 5-HT2A and 2B serotonin receptors, were performed. Three weeks after the interventions, whole blood, plasma, serum, and liver specimens were obtained for the following studies: peripheral platelet counts, hemodynamics of serotonin, histopathological examination, immunostaining, and quantification of mRNA expression. RESULTS: CONCLUSION: Our results showed that splenectomy promoted liver regeneration by increasing serotonin content in liver even under cirrhotic conditions.
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Authors | Yoshihiro Nagao, Tomohiko Akahoshi, Masahiro Kamori, Hideo Uehara, Naotaka Hashimoto, Nao Kinjo, Ken Shirabe, Akinobu Taketomi, Morimasa Tomikawa, Makoto Hashizume, Yoshihiko Maehara |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 41
Issue 8
Pg. 784-94
(Aug 2011)
ISSN: 1872-034X [Electronic] Netherlands |
PMID | 21699634
(Publication Type: Journal Article)
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Copyright | © 2011 The Japan Society of Hepatology. |