[A case of marked efficacy of low-dose UFT against metastatic bladder cancer].

Abstract

The two regimens of treatment consisted of either cisplatin and gemcitabine or methotrexate, vinblastine, doxorubicin and cisplatin(M-VAC), which has been widely adopted for muscle-invasive bladder cancer. But because of its potential toxicity, its tolerability has been troublesome, especially for very elderly patients. Herein, we report a bladder cancer case with multiple metastases which were controlled by low-dose UFT. At the same time, the chemosensitivity of 5-FU combined with uracylor 5-chloro-2, 4-dihydroxypyridine(CDHP). Four invasive bladder cancer cell lines were evaluated with a collagen gel droplet embedded drug sensitivity test(CD-DST). Three of four cell lines showed an increasing sensitivity to 5-FU with the combination of uracilor CDHP. Examinations with CD-DST may provide important scientific evidence for determining suitable chemotherapy for patients with advanced bladder cancer.

• Authors: Makoto Satoh, Osamu Nakano, Masaaki Kuwahara, Akihiro Ito, Yoichi Arai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 6 Pg. 1029-33 (Jun 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21677502 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Tegafur
• Uracil

Topics

• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Female
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Lung Neoplasms (drug therapy, secondary)
• Lymphatic Metastasis
• Neoplasm Invasiveness
• Recurrence
• Tegafur (therapeutic use)
• Tomography, X-Ray Computed
• Uracil (therapeutic use)
• Urinary Bladder Neoplasms (drug therapy, pathology, surgery)