Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity.

Abstract

OBJECTIVE:

Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin release-inhibiting factor (SRIF)) reportedly inhibits plasma PYY concentrations in animals and healthy humans, but the effect of a SRIF infusion on spontaneous PYY secretion in AN and OB is unknown.

METHODS:

A total of 18 young women, seven with acute AN (A-AN), four with AN in the recovery phase (R-AN), and seven with morbid OB, were studied. All subjects underwent an infusion of SRIF (9 μg/kg i.v./h, over 60 min), with blood samples drawn before and at different time intervals after SRIF administration. Plasma PYY levels were measured at each time point.

RESULTS:

SRIF significantly inhibited plasma PYY concentrations in R-AN and OB, without affecting PYY titers in A-AN. In OB, the inhibitory effect of SRIF also persisted at 90 min. Withdrawal of SRIF infusion in R-AN resulted in a prompt restoration of basal plasma PYY levels, whereas termination of SRIF infusion in OB was followed by a slower increase of PYY titers toward baseline levels. After infusion, PYY Δ area under the curve (ΔAUC) in R-AN was significantly higher than those in A-AN and OB patients. A significant difference in PYY ΔAUC between A-AN and OB was present.

CONCLUSIONS:

These results suggest the existence of a hypo- and hyper-sensitivity of L cells to the inhibitory effect of SRIF in A-AN and OB respectively.

• Authors: Antonello E Rigamonti, Silvano G Cella, Sara M Bonomo, Giuseppe Mancia, Guido Grassi, Mario Perotti, Fiorenza Agosti, Alessandro Sartorio, Eugenio E Müller, Angela I Pincelli
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 165 Issue 3 Pg. 421-7 (Sep 2011) ISSN: 1479-683X [Electronic] England
• PMID: 21677050 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide YY
• Somatostatin

Topics

• Adolescent
• Adult
• Anorexia Nervosa (physiopathology)
• Body Mass Index
• Female
• Humans
• Obesity, Morbid (physiopathology)
• Peptide YY (blood, metabolism)
• Postprandial Period
• Somatostatin