Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study.
Abstract | BACKGROUND: METHODS: RESULTS: One hundred twenty patients (63 placebo and 57 gabapentin) were studied. Pain scores did not significantly differ at any time point (P = 0.53). Parenteral and oral opioid consumption was not significantly different between groups on postoperative day 1 or 2 (P > 0.05 in both cases). The frequency of side effects such as nausea and vomiting or respiratory depression was not significantly different between groups, but gabapentin was associated with decreased frequency of pruritus requiring nalbuphine (14% gabapentin vs. 43% control group, P < 0.001). The frequency of patients experiencing pain at 3 months post- thoracotomy was also comparable between groups (70% gabapentin vs. 66% placebo group, P = 0.72). CONCLUSIONS: A single preoperative oral dose of gabapentin (600 mg) did not reduce pain scores or opioid consumption following elective thoracotomy, and did not confer any analgesic benefit in the setting of effective multimodal analgesia that included thoracic epidural infusion.
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Authors | Michelle A O Kinney, Carlos B Mantilla, Paul E Carns, Melissa A Passe, Michael J Brown, W Michael Hooten, Timothy B Curry, Timothy R Long, C Thomas Wass, Peter R Wilson, Toby N Weingarten, Marc A Huntoon, Richard H Rho, William D Mauck, Juan N Pulido, Mark S Allen, Stephen D Cassivi, Claude Deschamps, Francis C Nichols, K Robert Shen, Dennis A Wigle, Sheila L Hoehn, Sherry L Alexander, Andrew C Hanson, Darrell R Schroeder |
Journal | Pain practice : the official journal of World Institute of Pain
(Pain Pract)
Vol. 12
Issue 3
Pg. 175-83
(Mar 2012)
ISSN: 1533-2500 [Electronic] United States |
PMID | 21676165
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Copyright | © 2011 The Authors. Pain Practice © 2011 World Institute of Pain. |
Chemical References |
- Amines
- Analgesics
- Analgesics, Opioid
- Cyclohexanecarboxylic Acids
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Aged
- Amines
(adverse effects, therapeutic use)
- Analgesics
(adverse effects, therapeutic use)
- Analgesics, Opioid
(therapeutic use)
- Anesthesia, Epidural
- Cyclohexanecarboxylic Acids
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Gabapentin
- Humans
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy, prevention & control)
- Thoracotomy
- gamma-Aminobutyric Acid
(adverse effects, therapeutic use)
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