Evaluation of a new polysulfone hemofilter for continuous renal replacement therapy.

Abstract

New strategies using continuous renal replacement therapy as a tool to achieve immunomodulation in septic acute kidney injury have been proposed. The hypothesis is based on the possibility to remove inflammatory mediators and oxidants in a wide spectrum of molecular weights, thanks to new, highly permeable synthetic membranes. A new polysulfone hemofilter with high permeability and a sharp high cut-off membrane (CUREFLO™; Asahi Kasei Kuraray Medical Co., Ltd., Tokyo, Japan) has been evaluated in this study to assess IL-6 and advanced oxidation protein product removal in critically ill patients undergoing continuous renal replacement therapy. Unit performance, sieving coefficients and clearances were evaluated in fourteen patients undergoing continuous veno-venous hemofiltration and continuous veno-venous hemodialysis.

• Authors: Matteo Floris, Nicola Marchionna, Anna Clementi, Jeong Chul Kim, Dinna N Cruz, Federico Nalesso, Monica Zanella, Francesco Garzotto, Massimo de Cal, Grazia Maria Virzì, Alessandra Brendolan, Claudio Ronco
• Journal: Blood purification (Blood Purif) Vol. 32 Issue 2 Pg. 133-8 ( 2011) ISSN: 1421-9735 [Electronic] Switzerland
• PMID: 21654165 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Chemical References

• Interleukin-6
• Membranes, Artificial
• Polymers
• Sulfones
• beta 2-Microglobulin
• polysulfone P 1700
• Uric Acid
• Urea
• Creatinine

Topics

• Acute Kidney Injury (blood, physiopathology, therapy)
• Adsorption
• Creatinine (blood)
• Hemodynamics
• Hemofiltration (instrumentation, methods)
• Humans
• Interleukin-6 (blood)
• Kinetics
• Membranes, Artificial
• Middle Aged
• Oxidation-Reduction
• Permeability
• Polymers (chemistry, metabolism)
• Prospective Studies
• Renal Dialysis (instrumentation, methods)
• Sulfones (chemistry, metabolism)
• Urea (blood)
• Uric Acid (analysis, blood)
• beta 2-Microglobulin (blood)