Hyperinsulinemia may promote growth without GH in children after resection of suprasellar brain tumors.

Abstract

It remains elusive what factors induce growth without growth hormone (GWGH) in children after neurosurgery of brain tumors. Growth velocity and endocrinological data were compared between the patients with and without GWGH. We experienced three patients with GWGH (median, 12 years; 2 germinoma and 1 craniopharyngioma; three females; group 1) and 11 patients without (12 years; 8 craniopharyngioma, 2 germinoma and 1 medulloblastoma; 7 males; group 2) after neurosurgery. All patients in group 2 received GH replacement therapy. Growth velocity and endocrinological data were compared. Median height velocity was normal in group 1 (5.5 cm/year), but low in group 2 (2.2 cm/year), which improved after GH replacement therapy (7.0 cm/year). Median serum insulin level was increased in group 1 (87.0 μU/ml, P < 0.05) compared with normal level in group 2 (10.0 μU/ml). Despite hyperinsulinemia, serum glucose level was normal in group 1. Three of 5 with hyperinsulinemia and 2 of 9 without were obese or overweight, but the difference was not significant. Current body mass index and serum levels of IGF-1, IGFBP-3, leptin, and prolactin were similar between groups. Serum estradiol was prepuberty level in group 1. Hyperinsulinemia may induce GWGH in children with brain tumors after neurosurgery.

• Authors: Hideyuki Iwayama, Takashi Kamijo, Norishi Ueda
• Journal: Endocrine (Endocrine) Vol. 40 Issue 1 Pg. 130-3 (Aug 2011) ISSN: 1559-0100 [Electronic] United States
• PMID: 21638141 (Publication Type: Comparative Study, Letter)

Chemical References

• Insulin-Like Growth Factor Binding Protein 3
• Leptin
• Insulin-Like Growth Factor I
• Prolactin
• Growth Hormone

Topics

• Adolescent
• Brain Neoplasms (blood, surgery)
• Child
• Child, Preschool
• Craniopharyngioma (blood, surgery)
• Female
• Germinoma (blood, surgery)
• Growth (drug effects, physiology)
• Growth Hormone (pharmacology, therapeutic use)
• Humans
• Hyperinsulinism (physiopathology)
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (metabolism)
• Leptin (blood)
• Male
• Medulloblastoma (blood, surgery)
• Neurosurgical Procedures
• Prolactin (blood)
• Retrospective Studies
• Young Adult