The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.

Abstract

The sensitivity to clofazimine, B669 and eight standard anti-tumour chemotherapeutic agents of four intrinsically multidrug resistant (MDR) cell lines [three human hepatocellular carcinoma cell lines (HepG2, PLC and Mahlavu) and a human colorectal carcinoma cell line (CaCo2)] were compared with that of a human cervix epithelioid carcinoma cell line (HeLa). The MDR cell lines and HeLa cells showed equivalent sensitivity to the riminophenazines, methotrexate and 5-fluorouracil, but exhibited ranging levels of resistance to vinblastine, doxorubicin, mitomycin C, daunorubicin, etoposide and vincristine. Riminophenazines may be useful agents in the chemotherapy of tumours with intrinsic MDR.

• Authors: C Vanrensburg, A Theron, P Chasen
• Journal: Oncology reports (Oncol Rep) Vol. 3 Issue 1 Pg. 103-6 (Jan 1996) ISSN: 1021-335X [Print] Greece
• PMID: 21594323 (Publication Type: Journal Article)