The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels.

Abstract

Background. We used a random sample (n = 2, 495) from the population-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study population to examine the association of the metabolic syndrome (Met S) with plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) antigen levels. Results. The overall prevalence of the Met S was 18%, was dependent on age and gender, and was positively associated with higher antigen levels of both PAI-1 and t-PA. These significant effects were maintained after adjustment for age, gender, BMI, elevated C-reactive protein, smoking status, urinary albumin excretion, and insulin levels. We found no significant interactions between the Met S and other covariates on PAI-1 and t-PA levels. Conclusions. Our study demonstrates that those with the Met S have significantly higher levels of PAI-1 and t-PA antigen, factors known to increase the risk of cardiovascular disease.

• Authors: Christopher S Coffey, Folkert W Asselbergs, Patricia R Hebert, Hans L Hillege, Qing Li, Jason H Moore, Wiek H van Gilst
• Journal: Cardiology research and practice (Cardiol Res Pract) Vol. 2011 Pg. 541467 (Apr 04 2011) ISSN: 2090-0597 [Electronic] United States
• PMID: 21559217 (Publication Type: Journal Article)