Abstract | BACKGROUND: METHODOLOGY/PRINCIPAL FINDINGS: We performed a cross-sectional study of 88 Chinese patients with PD and VP using a clinical interview and the measurement of plasma Hcy and CRP to determine if Hcy and CRP levels in patients may predict the outcomes of the motor status, non-motor symptoms (NMS), disease severity, and cognitive declines. Each patient's NMS, cognitive deficit, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), Mini-Mental State Examination (MMSE), the modified Hoehn and Yahr staging scale (H&Y), and the unified Parkinson's disease rating scale part III (UPDRS III), respectively. We found that 100% of patients with PD and VP presented with NMS. The UPDRS III significantly correlated with CRP (P = 0.011) and NMSS (P = 0.042) in PD patients. The H&Y was also correlated with Hcy (P = 0.002), CRP (P = 0.000), and NMSS (P = 0.023) in PD patients. In VP patients, the UPDRS III and H&Y were not significantly associated with NMSS, Hcy, CRP, or MMSE. Strong correlations were observed between Hcy and NMSS as well as between CRP and NMSS in PD and VP. CONCLUSIONS/SIGNIFICANCE: Our findings support the hypothesis that Hcy and CRP play important roles in the pathogenesis of PD. The combination of Hcy and CRP may be used to assess the progression of PD and VP. Whether or not anti-inflammatory medication could be used in the management of PD and VP will produce an interesting topic for further research.
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Authors | Limin Zhang, Junqiang Yan, Yunqi Xu, Ling Long, Cansheng Zhu, Xiaohong Chen, Ying Jiang, Lijuan Yang, Lianfang Bian, Qing Wang |
Journal | PloS one
(PLoS One)
Vol. 6
Issue 4
Pg. e19333
(Apr 27 2011)
ISSN: 1932-6203 [Electronic] United States |
PMID | 21556377
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Homocysteine
- C-Reactive Protein
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Topics |
- Adult
- Aged
- C-Reactive Protein
(metabolism)
- China
- Cross-Sectional Studies
- Female
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Parkinson Disease
(metabolism, pathology)
- Parkinsonian Disorders
(metabolism, pathology)
- Vascular Diseases
(metabolism, pathology)
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