Resection after intraarterial chemotherapy of a hepatoblastoma originating in the caudate lobe.

Abstract

A rare case of hepatoblastoma originating in the caudate lobe was treated successfully with intraarterial chemotherapy followed by extensive lobectomy of the left side of the liver. Imaging modalities demonstrated a solitary huge tumor, initially inoperable, occupying almost the entire liver in a 4-month-old female infant. Transcatheter intrahepatic arterial chemotherapy with 10 mg doxorubicin, 20 mg cisplatin, and 3 ml Lipiodol, repeated twice at a 1-month interval, led to a remarkable reduction in tumor size and thereby made it resectable. The volume ratio between the intact hepatic parenchyma and the tumor changed from 1:1.70 to 1:0.13, as assessed by serial computed tomography scans, and the patient's initial alpha-fetoprotein level of 223,210 ng/ml declined to 53 ng/ml. The present case is the first in the literature, to our knowledge, of a resected hepatoblastoma in the caudate lobe. Clinical details of the tumor and surgical issues are discussed.

• Authors: T Takayama, M Makuuchi, K Takayasu, B LeThai, H Ohyama, S Yamazaki, H Hasegawa
• Journal: Surgery (Surgery) Vol. 107 Issue 2 Pg. 231-5 (Feb 1990) ISSN: 0039-6060 [Print] United States
• PMID: 2154056 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodized Oil
• Doxorubicin
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Hepatocellular (diagnostic imaging, drug therapy, pathology, surgery)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Doxorubicin (administration & dosage)
• Female
• Humans
• Infant
• Infusions, Intra-Arterial
• Iodized Oil (administration & dosage)
• Liver Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Tomography, X-Ray Computed