Vitreous inflammatory factors in macular edema with central retinal vein occlusion.

Abstract

PURPOSE:

To investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) and vascular endothelial growth factor (VEGF) with macular edema in patients with central retinal vein occlusion (CRVO).

METHODS:

Twenty-nine patients who had CRVO with macular edema and 16 patients with non-ischemic ocular diseases (control group) participated. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with fluorescein angiography and the public domain Scion Image program. Macular edema was examined by optical coherence tomography. Vitreous samples were obtained during pars plana vitrectomy. VEGF and sICAM-1 levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay.

RESULTS:

The median vitreous levels of VEGF and sICAM-1 were significantly higher in the CRVO patients than in the control group [366 vs. 15.6 pg/ml (P < 0.001) and 20.5 vs. 5.0 ng/ml (P < 0.001), respectively]. Vitreous levels of both VEGF and sICAM-1 were also significantly higher in the CRVO patients who had retinal ischemia than in those without ischemia (P < 0.001 and P = 0.011, respectively). Vitreous levels of VEGF and sICAM-1 were also significantly correlated with the severity of macular edema (P = 0.004 and P = 0.012, respectively).

CONCLUSIONS:

VEGF and sICAM-1 may both increase vascular permeability in CRVO patients with macular edema, with sICAM-1 acting together with and/or via VEGF.

• Authors: Hidetaka Noma, Hideharu Funatsu, Seiyo Harino, Tatsuya Mimura, Shuichiro Eguchi, Sadao Hori
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 55 Issue 3 Pg. 248-255 (May 2011) ISSN: 1613-2246 [Electronic] Japan
• PMID: 21538003 (Publication Type: Journal Article)

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Intercellular Adhesion Molecule-1

Topics

• Aged
• Enzyme-Linked Immunosorbent Assay
• Female
• Fluorescein Angiography
• Humans
• Intercellular Adhesion Molecule-1 (metabolism)
• Laser Coagulation
• Macular Edema (diagnosis, etiology, metabolism, surgery)
• Male
• Retinal Vein Occlusion (complications, diagnosis, metabolism, surgery)
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (metabolism)
• Visual Acuity
• Vitrectomy
• Vitreous Body (metabolism)