Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.

Abstract	Reactive oxygen species (ROS) formation has been found to induce the brain damage following stroke-like events. The aim of the present study was to investigate the effect of Stachybotrys microspora triprenyl phenol-7 (SMTP-7) on the generation of ROS in ischemia-induced cerebral infarction model and in vitro lipid peroxidation. We used immunohistochemistry and real-time reverse-transcription PCR for ex vivo evaluation and thiobarbituric acid-reactive substance reagent assay for in vitro evaluation. We demonstrated that SMTP-7 did not induce enhancement of 4-hydroxynonenal or neutrophil cytosolic factor 2 like t-PA administration at 3 h after ischemia ex vivo and reduce lipid peroxidation in vitro. This compound is the first low molecular weight compound with triplet activities of thrombolytic, anti-inflammatory, and antioxidant activities. We theorized that SMTP-7 is among the pharmacological agents that reduce ROS formation and have been found to limit the extent of brain damage following stroke-like events.
Authors	Keita Shibata, Terumasa Hashimoto, Koji Nobe, Keiji Hasumi, Kazuo Honda
Journal	Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol) Vol. 384 Issue 1 Pg. 103-8 (Jul 2011) ISSN: 1432-1912 [Electronic] Germany
PMID	21533990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Aldehydes Benzopyrans Ferrous Compounds Free Radical Scavengers Neuroprotective Agents Pyrrolidinones Reactive Oxygen Species SMTP 7 Thiobarbituric Acid Reactive Substances NADPH Oxidases Ncf2 protein, mouse Tissue Plasminogen Activator 4-hydroxy-2-nonenal Edaravone Antipyrine
Topics	Aldehydes (metabolism) Animals Antipyrine (analogs & derivatives, pharmacology) Benzopyrans (pharmacology, therapeutic use) Brain (drug effects, metabolism) Cerebral Infarction (drug therapy, metabolism, prevention & control) Disease Models, Animal Edaravone Ferrous Compounds (pharmacology) Free Radical Scavengers (pharmacology, therapeutic use) Gene Expression (drug effects, genetics) Lipid Peroxidation (drug effects) Male Mice Mice, Inbred Strains NADPH Oxidases (genetics) Neuroprotective Agents (pharmacology, therapeutic use) Pyrrolidinones (pharmacology, therapeutic use) Reactive Oxygen Species (metabolism) Real-Time Polymerase Chain Reaction Thiobarbituric Acid Reactive Substances (metabolism) Tissue Plasminogen Activator (pharmacology, therapeutic use)

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