Sedative, vasorelaxant, and cytotoxic effects of convolvulin from Ipomoea tyrianthina.

Abstract

AIM OF THE STUDY:

Ipomoea tyrianthina has been used in Mexican traditional medicine as a mild purgative, for the treatment of nervous disorders, and against tumors. In this study, the effect of convolvulin (an ether-insoluble resin glycoside) from the root of Ipomoea tyrianthina on: Central Nervous System; as spasmolytic and vasodilator; cytotoxic against cancer cell lines is evaluated.

MATERIALS AND METHODS:

Convolvulin isolated from the root of Ipomoea tyrianthina (IT-EM) was tested on pentylentetrazole induced seizures, pentobarbital-induced hypnosis, release of GABA and glutamic acid, isolated rat aorta and ileum rings, and against Caco-2 and KB cell lines.

RESULTS:

IT-EM increased the hypnotic effect induced by pentobarbital and the release of GABA in brain cortex of mice, but did not protect mice against pentylenetetrazole-induced convulsions. IT-EM produced a significant vasodilator effect in concentration- and endothelium-dependent manners on isolated rat aorta, but did not inhibit significantly contractions on rat ileum, colon, and jejune rings. IT-EM showed cytotoxic activity against nasopharyngeal carcinoma KB cell line.

CONCLUSIONS:

Convolvulin (IT-EM) from Ipomoea tyrianthina has sedative effect, vasorelaxant effect in concentration- and endothelium-dependent manners, and cytotoxic activity against nasopharyngeal carcinoma KB cell line.

• Authors: Ismael León-Rivera, Maribel Herrera-Ruiz, Samuel Estrada-Soto, María del Carmen Gutiérrez, Iván Martínez-Duncker, Gabriel Navarrete-Vázquez, María Yolanda Rios, Berenice Aguilar, Patricia Castillo-España, Alma Aguirre-Moreno
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 135 Issue 2 Pg. 434-9 (May 17 2011) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 21440616 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Glycosides
• Hypnotics and Sedatives
• Plant Extracts
• Resins, Plant
• Vasodilator Agents
• convolvulin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Glycosides (pharmacology)
• Humans
• Hypnotics and Sedatives (pharmacology)
• Ipomoea (chemistry)
• Mice
• Plant Extracts (chemistry)
• Resins, Plant (pharmacology)
• Vasodilator Agents (pharmacology)