Esophageal carcinosarcoma presenting as a fever with elevated serum interleukin-6.

Abstract

We report a patient with esophageal carcinosarcoma who initially presented with fever. A 57-year-old man with a 4-month history of intermittent fever was referred to our hospital and diagnosed as having esophageal carcinosarcoma. High fever persisted and serum concentration of interleukin-6 was markedly elevated. In contrast, after thoracic esophagectomy, the fever subsided and interleukin-6 serum levels rapidly normalized. The clinical course of the patient suggests that the tumor produced interleukin-6 and this was associated not only with inflammation, but also the aggressive biologic behavior of the tumor.

• Authors: Satoshi Hayama, Shunichi Okushiba, Toshiaki Shichinohe, Satoshi Hirano, Eiichi Tanaka, Satoshi Kondo
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 91 Issue 4 Pg. 1288-90 (Apr 2011) ISSN: 1552-6259 [Electronic] Netherlands
• PMID: 21440168 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Chemical References

• Interleukin-6

Topics

• Carcinosarcoma (blood, complications, diagnosis)
• Esophageal Neoplasms (blood, complications, diagnosis)
• Fever (etiology)
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged