[Effective chemotherapy with S-1 alone in a patient with lung metastases of breast cancer].

Abstract

We report a 50-year-old female with pulmonary metastases from breast cancer who responded to S-1. In September 2003, she underwent surgery for breast cancer. Four years 8 months after the operation, lung relapse was detected. After the treatment failure of FEC60 (5-FU 500 mg/m², epirubicin 60 mg/m², cyclophosphamide 500 mg/m²) and taxane antitumor drugs, oral administration of S-1 80 mg/body/day was initiated. At the end of three courses, thoracic CT revealed the disappearance of the lung metastasis. Advanced reactions during the administration period were mild. After 14 courses of S-1 therapy (during 11 months), a complete response was clinically maintained. S-1 showed a good antitumor effect and tolerance, and it might be useful for treating metastatic and recurrent breast cancers.

• Authors: Kenichi Tazawa, Yasunori Tsuchiya, Masahiro Shinbo, Fuminori Yamagishi, Katsuo Shimada, Koshi Matsui, Takuya Nagata, Yutaka Shimada, Kazuhiro Tsukada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 3 Pg. 423-5 (Mar 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21403446 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Antimetabolites, Antineoplastic (therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Drug Combinations
• Female
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Middle Aged
• Oxonic Acid (therapeutic use)
• Tegafur (therapeutic use)
• Tomography Scanners, X-Ray Computed