Abstract | BACKGROUND: METHODS: We conducted a retrospective review of histopathologically confirmed NETs of the stomach at our hospital between January 2000 and August 2006. RESULTS: Thirty-seven NETs were identified. Fifteen patients had carcinoids while 22 had PNECs. Among the carcinoid patients, 7 underwent endoscopic mucosal resection and 5 had gastrectomy as first-line treatment. Three patients were observed without intervention. All patients were alive after an average follow-up period of 27 months. Among the 22 PNEC patients, 3 had no metastasis, 11 had regional lymph node metastasis, and 8 had distant metastasis. Eight of 14 patients relapsed at a median of 177 days (range 120-1459 days) after curative surgery. Twelve patients with metastatic or recurrent disease received palliative cisplatin plus irinotecan chemotherapy. The response rate was 75%, the median progression-free survival time was 212 days, and median survival time was 679 days. CONCLUSION: Gastric PNEC patients with distant metastasis had poor outcomes. Regimens containing cisplatin plus irinotecan produced a good response in gastric PNEC.
|
Authors | Natsuko Tsuda Okita, Ken Kato, Daisuke Takahari, Yoshinori Hirashima, Takako E Nakajima, Junichi Matsubara, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Hirokazu Taniguchi, Kuniaki Shirao |
Journal | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
(Gastric Cancer)
Vol. 14
Issue 2
Pg. 161-5
(Jun 2011)
ISSN: 1436-3305 [Electronic] Japan |
PMID | 21327441
(Publication Type: Historical Article, Journal Article)
|
Chemical References |
- Irinotecan
- Cisplatin
- Camptothecin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Carcinoma, Neuroendocrine
(drug therapy, mortality)
- Cisplatin
(administration & dosage)
- Disease-Free Survival
- Female
- History, 17th Century
- Humans
- Irinotecan
- Kaplan-Meier Estimate
- Male
- Retrospective Studies
- Stomach Neoplasms
(drug therapy, mortality)
|