Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSION:
Pranlukast protects endothelial cells from H2O2-induced necrosis by inhibiting ROS-mediated collapse of mitochondrial membrane potential, and this is leukotriene-independent.
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Authors | Rui Zhao, San-Hua Fang, Ka-Na Lin, Xue-Qin Huang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing Wei |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 57
Issue 4
Pg. 479-88
(Apr 2011)
ISSN: 1533-4023 [Electronic] United States |
PMID | 21283018
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chromones
- Leukotriene Antagonists
- Reactive Oxygen Species
- Hydrogen Peroxide
- L-Lactate Dehydrogenase
- pranlukast
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Topics |
- Cell Line
- Cell Survival
(drug effects)
- Chromones
(pharmacology)
- Dose-Response Relationship, Drug
- Endothelial Cells
(drug effects, metabolism)
- Humans
- Hydrogen Peroxide
(administration & dosage, toxicity)
- L-Lactate Dehydrogenase
(drug effects, metabolism)
- Leukotriene Antagonists
(pharmacology)
- Membrane Potential, Mitochondrial
(drug effects)
- Necrosis
(drug therapy, pathology)
- Oxidative Stress
(drug effects)
- Reactive Oxygen Species
(metabolism)
- Time Factors
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